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1

Chemical synthesis and biological evaluation of novel epothilone B and trans-12,13-cyclopropyl epothilone B analogues

K.C Nicolaou, Andreas Ritzén, Kenji Namoto, Rubén M Buey, J.Fernando Dı́az, José M Andreu, Markus Wartmann, Karl-Heinz Altmann, Aurora O'Brate, Paraskevi Giannakakou

Journal:

Year:

2002

Language:

english

File:

PDF, 617 KB

english, 2002

2

Design, Synthesis, and Biological Properties of Highly Potent Epothilone B Analogues

K. C. Nicolaou, Pradip K. Sasmal, Gerasimos Rassias, Mali Venkat Reddy, Karl-Heinz Altmann, Markus Wartmann, Aurora O'Brate, Paraskevi Giannakakou

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 200 KB

english, 2003

3

Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer

Giannakakou, Paraskevi, Poy, George, Zhan, Zhirong, Knutsen, Turid, Blagosklonny, Mikhail V, Fojo, Tito

Journal:

Year:

2000

Language:

english

File:

PDF, 353 KB

english, 2000

4

A Bayesian machine learning approach for drug target identification using diverse data types

Madhukar, Neel S., Khade, Prashant K., Huang, Linda, Gayvert, Kaitlyn, Galletti, Giuseppe, Stogniew, Martin, Allen, Joshua E., Giannakakou, Paraskevi, Elemento, Olivier

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 3.83 MB

english, 2019

5

Microtubule engagement with taxane is altered in taxane-resistant gastric cancer

Galletti, Giuseppe, Zhang, Chao, Gjyrezi, Ada, Cleveland, Kyle, Zhang, Jiaren, Powell, Sarah, Thakkar, Prashant V, Betel, Doron, Shah, Manish A, Giannakakou, Paraskevi

Journal:

Clinical Cancer Research

Year:

2020

File:

PDF, 5.29 MB

2020

6

Combinations of pacliataxel and vinblastine and their effects on tublin polymerization and cellular cytotoxicity: Characterization of a synergistic schedule

Paraskevi Giannakakou, Lourdes Villalba, Hang Li, Marianne Poruchynsky, Tito Fojo

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 241 KB

english, 1998

7

Synthesis and Biological Evaluation of 12,13-Cyclopropyl and 12,13-Cyclobutyl Epothilones

K. C. Nicolaou, Kenji Namoto, Jim Li, Andreas Ritzén, Trond Ulven, Mitsuru Shoji, Dan Zaharevitz, Rick Gussio, Dan L. Sackett, Rita D. Ward, Anne Hensler, Tito Fojo, Paraskevi Giannakakou

Journal:

Year:

2001

Language:

english

File:

PDF, 272 KB

english, 2001

8

Design, Synthesis, and Biological Properties of Highly Potent Epothilone B Analogues

K. C. Nicolaou, Pradip K. Sasmal, Gerasimos Rassias, Mali Venkat Reddy, Karl-Heinz Altmann, Markus Wartmann, Aurora O'Brate, Paraskevi Giannakakou

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 200 KB

english, 2003

9

Total Synthesis and Biological Evaluation of (−)Apicularen A and Analogues Thereof

K. C. Nicolaou, David W. Kim, Rachid Baati, Aurora O′Brate, Paraskevi Giannakakou

Journal:

Chemistry - A European Journal

Year:

2003

Language:

english

File:

PDF, 406 KB

english, 2003

10

ChemInform Abstract: Synthesis of Epothilones A and B in Solid and Solution Phase.

K. C. NICOLAOU, N. WINSSINGER, J. PASTOR, S. NINKOVIC, F. SARABLA, Y. HE, D. VOURLOUMIS, Z. YANG, T. LI, P. GIANNAKAKOU, E. HAMEL

Journal:

Year:

1997

File:

PDF, 31 KB

1997

11

Chemical Synthesis and Biological Evaluation of Novel Epothilone B and trans-12,13-Cyclopropyl Epothilone B Analogues.

K. C. Nicolaou, Andreas Ritzen, Kenji Namoto, Ruben M. Buey, J. Fernando Diaz, Jose M. Andreu, Markus Wartmann, Karl-Heinz Altmann, Aurora O'Brate, Paraskevi Giannakakou

Journal:

Year:

2002

File:

PDF, 25 KB

2002

12

Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation.

K. C. Nicolaou, Yiwei Li, Kazuyuki Sugita, Holger Monenschein, Prasuna Guntupalli, Helen J. Mitchell, Konstantina C. Fylaktakidou, Dionisios Vourloumis, Paraskevi Giannakakou, Aurora O'Brate

Journal:

Year:

2004

File:

PDF, 50 KB

2004

13

Total Synthesis and Biological Evaluation of (-)-Apicularen A and Analogues Thereof

K. C. Nicolaou, David W. Kim, Rachid Baati, Aurora O'Brate, Paraskevi Giannakakou

Journal:

Year:

2004

File:

PDF, 60 KB

2004

14

Studies Toward Diazonamide A: Development of a Hetero-Pinacol Macrocyclization Cascade for the Construction of the Bis-Macrocyclic Framework of the Originally Proposed Structure.

K. C. Nicolaou, Scott A. Snyder, Nicolas Giuseppone, Xianhai Huang, Marco Bella, Mali V. Reddy, Paraselli Bheema Rao, Alexandros E. Koumbis, Paraskevi Giannakakou, Aurora O'Brate

Journal:

Year:

2004

File:

PDF, 8 KB

2004

15

Molecular Design and Chemical Synthesis of a Highly Potent Epothilone

K. C. Nicolaou, Benjamin A. Pratt, Stellios Arseniyadis, Markus Wartmann, Aurora O'Brate, Paraskevi Giannakakou

Journal:

Year:

2006

Language:

english

File:

PDF, 126 KB

english, 2006

16

Cover Picture: Molecular Design and Chemical Synthesis of a Highly Potent Epothilone (ChemMedChem 1/2006)

K. C. Nicolaou, Benjamin A. Pratt, Stellios Arseniyadis, Markus Wartmann, Aurora O'Brate, Paraskevi Giannakakou

Journal:

Year:

2006

File:

PDF, 45 KB

2006

17

Interaction of Epothilone Analogs with the Paclitaxel Binding Site: Relationship between Binding Affinity, Microtubule Stabilization, and Cytotoxicity

Rubén M. Buey, J.Fernando Dı́az, José M. Andreu, Aurora O'Brate, Paraskevi Giannakakou, K.C. Nicolaou, Pradip K. Sasmal, Andreas Ritzén, Kenji Namoto

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 355 KB

english, 2004

18

Microtubule Interactions with Chemically Diverse Stabilizing Agents: Thermodynamics of Binding to the Paclitaxel Site Predicts Cytotoxicity

Rubén M. Buey, Isabel Barasoain, Evelyn Jackson, Arndt Meyer, Paraskevi Giannakakou, Ian Paterson, Susan Mooberry, José M. Andreu, J. Fernando Díaz

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 444 KB

english, 2005

19

Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents

Dan L. Sackett, Paraskevi Giannakakou, Marianne Poruchynsky, Antonio Fojo

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.17 MB

english, 1997

20

Effect of calcium channel blockers on the action of various antitumour agents in the yeast Saccharomyces cerevisiae

E. Tiligada, P. Giannakakou, I. Karavokyros, A. Delitheos

Journal:

Journal of Applied Microbiology

Year:

1996

Language:

english

File:

PDF, 461 KB

english, 1996

21

10.1038/36382

Nicolaou, K. C., Winssinger, N., Pastor, J., Ninkovic, S., Sarabia, F., He, Y., Vourloumis, D., Yang, Z., Li, T., Giannakakou, P., Hamel, E.

Journal:

Year:

1997

Language:

english

File:

PDF, 551 KB

english, 1997

22

Synthesis of epothilones A and B in solid and solution phase

Li, T., Giannakakou, P., Nicolaou, K. C., Winssinger, N., Pastor, J., Ninkovic, S., Sarabia, F., He, Y., Vourloumis, D., Yang, Z.

Journal:

Year:

1997

File:

PDF, 1.02 MB

1997

23

Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

Giannakakou, Paraskevi, Robey, Robert, Fojo, Tito, Blagosklonny, Mikhail V

Journal:

Year:

2001

Language:

english

File:

PDF, 643 KB

english, 2001

24

Accumulation of hypoxia-inducible factor-1α is limited by transcription-dependent depletion

Demidenko, Zoya N, Rapisarda, AnnaMaria, Garayoa, Mercedes, Giannakakou, Paraskevi, Melillo, Giovanni, Blagosklonny, Mikhail V

Journal:

Year:

2005

Language:

english

File:

PDF, 241 KB

english, 2005

25

Chemical synthesis and biological properties of pyridine epothilones

KC Nicolaou, R Scarpelli, B Bollbuck, B Werschkun, MMA Pereira, M Wartmann, K-H Altmann, D Zaharevitz, R Gussio, P Giannakakou

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 314 KB

english, 2000

26

Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism

Marianne S. Poruchynsky, Paraskevi Giannakakou, Yvona Ward, J. Chloe Bulinski, William G. Telford, Robert W. Robey, Tito Fojo

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 416 KB

english, 2001

27

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF

Nicola J. Mabjeesh, Daniel Escuin, Theresa M. LaVallee, Victor S. Pribluda, Glenn M. Swartz, Michelle S. Johnson, Margaret T. Willard, Hua Zhong, Jonathan W. Simons, Paraskevi Giannakakou

Journal:

Year:

2003

Language:

english

File:

PDF, 739 KB

english, 2003

28

The importance of p53 location: nuclear or cytoplasmic zip code?

Aurora O’Brate, Paraskevi Giannakakou

Journal:

Drug Resistance Updates

Year:

2003

Language:

english

File:

PDF, 138 KB

english, 2003

29

Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[18F]fluoroethoxyestradiol for positron emission tomography

Jiyoung Mun, Yuefang Wang, Ronald J. Voll, Daniel Escuin-Borras, Paraskevi Giannakakou, Mark M. Goodman

Journal:

Nuclear Medicine and Biology

Year:

2008

Language:

english

File:

PDF, 377 KB

english, 2008

30

Carboplatin plus paclitaxel therapy after docetaxel in men with metastatic castrate resistant prostate cancer

Stephanie Jeske, Scott T. Tagawa, Olugbenga Olowokure, Jodi Selzer, Paraskevi Giannakakou, David M. Nanus

Journal:

Urologic Oncology: Seminars and Original Investigations

Year:

2011

Language:

english

File:

PDF, 301 KB

english, 2011

31

Reply

Rick Gussio, Tito Fojo, Paraskevi Giannakakou

Journal:

Trends in Pharmacological Sciences

Year:

2000

Language:

english

File:

PDF, 151 KB

english, 2000

32

Synthesis and Biological Evaluation of 2-Acyl Analogues of Paclitaxel (Taxol)

Kingston, David G. I., Chaudhary, Ashok G., Chordia, Mahendra D., Gharpure, Milind, Gunatilaka, A. A. Leslie, Higgs, Paul I., Rimoldi, John M., Samala, Lakshman, Jagtap, Prakash G., Giannakakou, Paras

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 204 KB

english, 1998

33

Studies toward Diazonamide A: Development of a Hetero-Pinacol Macrocyclization Cascade for the Construction of the Bis-Macrocyclic Framework of the Originally Proposed Structure

Nicolaou, K. C., Snyder, Scott A., Giuseppone, Nicolas, Huang, Xianhai, Bella, Marco, Reddy, Mali V., Rao, Paraselli Bheema, Koumbis, Alexandros E., Giannakakou, Paraskevi, O'Brate, Aurora

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 304 KB

english, 2004

34

O-189 The combination of farnesyltransferase inhibitors and taxolreverses taxol resistance by enhancing taxol binding to microtubules: Clinical implications for NSCLC therapy

O'Brate, A., Marcus, A., Giannakakou, P.

Journal:

Year:

2005

Language:

english

File:

PDF, 143 KB

english, 2005

35

O-192 Elucidation of the mechanism of taxane-mediated inhibition of the HIF pathway: New insight into taxane's antitumor and antiangiogenic activity in NSCLC

Escuin, D., O'Brate, A., Kline, E., Giannakakou, P.

Journal:

Year:

2005

Language:

english

File:

PDF, 143 KB

english, 2005

36

10.1038/35036335

Giannakakou, Paraskevi, Sackett, Dan L., Ward, Yvona, Webster, Kevin R., Blagosklonny, Mikhail V., Fojo, Tito

Journal:

Nature Cell Biology

Year:

2000

Language:

english

File:

PDF, 1.87 MB

english, 2000

37

The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP)

Basciano, Paul A., Bussel, James, Hafeez, Zeeshan, Christos, Paul J., Giannakakou, Paraskevi

Journal:

British Journal of Haematology

Year:

2013

Language:

english

File:

PDF, 312 KB

english, 2013

38

Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation

Nicolaou, K. C., Li, Yiwei, Sugita, Kazuyuki, Monenschein, Holger, Guntupalli, Prasuna, Mitchell, Helen J., Fylaktakidou, Konstantina C., Vourloumis, Dionisios, Giannakakou, Paraskevi, O'Brate, Aurora

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 670 KB

english, 2003

39

The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity †

Pryor, Donald E., O'Brate, Aurora, Bilcer, Geoffrey, Díaz, J. Fernando, Wang, Yuefang, Wang, Yong, Kabaki, Mikio, Jung, M. Katherine, Andreu, José M., Ghosh, Arun K., Giannakakou, Paraskevi, Hamel, Er

Journal:

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

40

Isolation and characterization of circulating tumor cells in prostate cancer

Diamond, Elan, Lee, Guang Yu, Akhtar, Naveed H., Kirby, Brian J., Giannakakou, Paraskevi, Tagawa, Scott T., Nanus, David M.

Journal:

Frontiers in Oncology

Year:

2012

Language:

english

File:

PDF, 2.10 MB

english, 2012

41

Chemistry and Biology of Diazonamide A: Second Total Synthesis and Biological Investigations

Nicolaou, K. C., Hao, Junliang, Reddy, Mali V., Rao, Paraselli Bheema, Rassias, Gerasimos, Snyder, Scott A., Huang, Xianhai, Chen, David Y.-K., Brenzovich, William E., Giuseppone, Nicolas, Giannakakou

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 292 KB

english, 2004

42

Evaluation of the Tubulin-Bound Paclitaxel Conformation: Synthesis, Biology, and SAR Studies of C-4 to C-3‘ Bridged Paclitaxel Analogues

Ganesh, Thota, Yang, Chao, Norris, Andrew, Glass, Tom, Bane, Susan, Ravindra, Rudravajhala, Banerjee, Abhijit, Metaferia, Belhu, Thomas, Shala L., Giannakakou, Paraskevi, Alcaraz, Ana A., Lakdawala, A

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 375 KB

english, 2007

43

Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer

Darshan, M. S., Loftus, M. S., Thadani-Mulero, M., Levy, B. P., Escuin, D., Zhou, X. K., Gjyrezi, A., Chanel-Vos, C., Shen, R., Tagawa, S. T., Bander, N. H., Nanus, D. M., Giannakakou, P.

Journal:

Cancer Research

Year:

2011

Language:

english

File:

PDF, 1.35 MB

english, 2011

44

BRCA1 regulates microtubule dynamics and taxane-induced apoptotic cell signaling

Sung, M, Giannakakou, P

Journal:

Year:

2014

Language:

english

File:

PDF, 2.60 MB

english, 2014

45

Circulating Tumor Cells in Prostate Cancer Diagnosis and Monitoring: An Appraisal of Clinical Potential

G. Galletti, L. Portella, S. T. Tagawa, B. J. Kirby, P. Giannakakou, D. M. Nanus

Journal:

Molecular Diagnosis & Therapy

Year:

2014

Language:

english

File:

PDF, 2.77 MB

english, 2014

46

Interaction of Epothilone Analogs with the Paclitaxel Binding SiteRelationship between Binding Affinity, Microtubule Stabilization, and Cytotoxicity

BUEY, R, DIAZ, J, ANDREU, J, OBRATE, A, GIANNAKAKOU, P, NICOLAOU, K, SASMAL, P, RITZEN, A, NAMOTO, K

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 355 KB

english, 2004

47

NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents

Harkcom, W. T., Ghosh, A. K., Sung, M. S., Matov, A., Brown, K. D., Giannakakou, P., Jaffrey, S. R.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.96 MB

english, 2014

48

Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer

Thadani-Mulero, M., Portella, L., Sun, S., Sung, M., Matov, A., Vessella, R. L., Corey, E., Nanus, D. M., Plymate, S. R., Giannakakou, P.

Journal:

Cancer Research

Year:

2014

Language:

english

File:

PDF, 2.26 MB

english, 2014

49

[IEEE 2006 International Conference on Image Processing - Atlanta Marriott Marquis, Atlanta, GA, USA (2006.10.8-2006.10.11)] 2006 International Conference on Image Processing - Ceulular Imaging Data Analysis: Mircotubule Dynamics in Living Cell

Kong, Koon, Marcus, Adam, Hong, Jin, Giannakakou, Paraskevi, Wang, May

Year:

2006

Language:

english

File:

PDF, 4.80 MB

english, 2006

50

Studies toward Diazonamide A: Development of a Hetero-Pinacol Macrocyclization Cascade for the Construction of the Bis-Macrocyclic Framework of the Originally Proposed Structure [ J. Am. Chem. Soc. 2004 , 126 , 10174−10182].

Nicolaou, K. C., Snyder, Scott A., Giuseppone, Nicolas, Huang, Xianhai, Bella, Marco, Reddy, Mali V., Bheema Rao, Paraselli, Koumbis, Alexandros E., Giannakakou, Paraskevi, O'Brate, Aurora

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 12 KB

english, 2004